Journalartikel - Wissenschaftlicher Artikel | 2023 | Peer reviewed

Synthesis and Evaluation of Radioiodinated Estrogens for Diagnosis and Therapy of Male Urogenital Tumours

Autor*innen

Braun, Feodor ; Jaschinski, Marcel ; Täger, Philipp ; Marmann, Verena ; Brandenstein, Melanie von ; Köditz, Barbara ; Fischer, Thomas ; Muñoz-Vázquez, Sergio ; Zimmermanns, Beate ; Dietlein, Markus ; Sudbrock, Ferdinand ; Krapf, Phillip ; Fischer, Dietmar ; Heidenreich, Axel ; Drzezga, Alexander ; Kirsch, Stefan ; Pietsch, Markus ; Schomäcker, Klaus

Zeitschrift

Organic & biomolecular chemistry

DOI

10.1039/d3ob00114h

URL

https://pubs.rsc.org/en/content/articlepdf/2023/ob/d3ob00114h

Weitere Details

Sprache

englisch

Darstellungsform

Text

Band

Ausgabe

Seitenbereich

3090 - 3095

The preparation of 24 estrogens, their estrogen receptor (ER) affinity and studies of radioiodinated estrogen binding to ER-positive male bladder tumor cells (HTB9) are described. The estrogens with the highest affinity were selected using fluorescence anisotropy assays. A 2,2,2-trifluoroethyl group at the 11β-position caused particularly promising affinity. (Radio)iodination was performed on the 17α-vinyl group. Binding studies on HTB9 cells revealed picomolar affinities of radioconjugates 19 and 31, indicating promising ability for targeting of urogenital tumors.

Zitierstile

Braun, F., Jaschinski, M., Täger, P., Marmann, V., Brandenstein, M. von, Köditz, B., … Schomäcker, K. (2023). Synthesis and Evaluation of Radioiodinated Estrogens for Diagnosis and Therapy of Male Urogenital Tumours. Organic & Biomolecular Chemistry, 21(15), 3090–3095. doi:10.1039/d3ob00114h

In die Zwischenablage kopieren

Braun, F., Jaschinski, M., Täger, P., Marmann, V., Brandenstein, M. von, Köditz, B., Fischer, T., Muñoz-Vázquez, S., Zimmermanns, B., Dietlein, M., Sudbrock, F., Krapf, P., Fischer, D., Heidenreich, A., Drzezga, A., Kirsch, S., Pietsch, M. and Schomäcker, K., 2023. Synthesis and Evaluation of Radioiodinated Estrogens for Diagnosis and Therapy of Male Urogenital Tumours. Organic & biomolecular chemistry, [online] 21(15), pp.3090–3095. Available at: <https://pubs.rsc.org/en/content/articlepdf/2023/ob/d3ob00114h>.

In die Zwischenablage kopieren

Braun, Feodor u. a. 2023. Synthesis and Evaluation of Radioiodinated Estrogens for Diagnosis and Therapy of Male Urogenital Tumours. Organic & biomolecular chemistry 21, 15, 3090–3095. https://pubs.rsc.org/en/content/articlepdf/2023/ob/d3ob00114h.

American Psychological Association 6th edition (DOI)

Anglia Ruskin University - Harvard

Gesellschaft für Bildung und Forschung in Europa - Harvard