@prefix ocrer: <http://purl.org/net/OCRe/research.owl#> .
@prefix owl:   <http://www.w3.org/2002/07/owl#> .
@prefix scires: <http://vivoweb.org/ontology/scientific-research#> .
@prefix xsd:   <http://www.w3.org/2001/XMLSchema#> .
@prefix skos:  <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs:  <http://www.w3.org/2000/01/rdf-schema#> .
@prefix ocresd: <http://purl.org/net/OCRe/study_design.owl#> .
@prefix swo:   <http://www.ebi.ac.uk/efo/swo/> .
@prefix cito:  <http://purl.org/spar/cito/> .
@prefix geo:   <http://aims.fao.org/aos/geopolitical.owl#> .
@prefix ocresst: <http://purl.org/net/OCRe/statistics.owl#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix vivo:  <http://vivoweb.org/ontology/core#> .
@prefix event: <http://purl.org/NET/c4dm/event.owl#> .
@prefix vann:  <http://purl.org/vocab/vann/> .
@prefix foaf:  <http://xmlns.com/foaf/0.1/> .
@prefix c4o:   <http://purl.org/spar/c4o/> .
@prefix fabio: <http://purl.org/spar/fabio/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix thkoeln: <http://cris.nrw/hisinone#> .
@prefix vitro: <http://vitro.mannlib.cornell.edu/ns/vitro/0.7#> .
@prefix vitro-public: <http://vitro.mannlib.cornell.edu/ns/vitro/public#> .
@prefix rdf:   <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix ocresp: <http://purl.org/net/OCRe/study_protocol.owl#> .
@prefix bibo:  <http://purl.org/ontology/bibo/> .
@prefix obo:   <http://purl.obolibrary.org/obo/> .
@prefix ro:    <http://purl.obolibrary.org/obo/ro.owl#> .

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                <https://fis.th-koeln.de/vivo/individual/publ_21423> .

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        rdfs:label  "Kontinuant"@de-DE , "Continuant"@en-US , "Continuant"@en .

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        a           thkoeln:Organisationseinheit , foaf:Agent , obo:BFO_0000001 , obo:BFO_0000004 , obo:BFO_0000002 , foaf:Organization , owl:Thing ;
        rdfs:label  "Fakultät für Angewandte Naturwissenschaften" ;
        <http://cris.nrw/hisinone/istOrganisationseinheitVon>
                <https://fis.th-koeln.de/vivo/individual/publ_21423> .

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        a       thkoeln:Zitat , owl:Thing .

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        rdfs:label  "Entität"@de-DE , "Entity"@en-US , "Entity"@en .

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        a       thkoeln:Zitat , owl:Thing .

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        a           owl:NamedIndividual , <http://cris.nrw/hisinone/ArtderRessource> , owl:Thing ;
        rdfs:label  "Text"@de-DE , "Text"@en-US .

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        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_21423> .

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        a       thkoeln:Zitat , owl:Thing .

thkoeln:Journalartikel
        a           owl:Class ;
        rdfs:label  "Journal Article"@en-US , "Journalartikel"@de-DE .

obo:IAO_0000030  a  owl:Class ;
        rdfs:label  "Entität für Informationsinhalt"@de-DE , "Information Content Entity"@en-US , "Information Content Entity"@en .

<https://fis.th-koeln.de/vivo/individual/aut_21423-2>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
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        a                         owl:Thing , thkoeln:Artikel , obo:BFO_0000001 , foaf:Document , obo:IAO_0000030 , obo:BFO_0000031 , thkoeln:Journalartikel , bibo:Document , thkoeln:Publikation , obo:BFO_0000002 ;
        rdfs:label                "RDF description of Digital Twin for Upstream and Downstream Integration of Virus-like Particle Manufacturing - https://fis.th-koeln.de/vivo/individual/publ_21423" , "Digital Twin for Upstream and Downstream Integration of Virus-like Particle Manufacturing" ;
        thkoeln:URL               "https://www.mdpi.com/2227-9717/13/7/2101/pdf?version=1751450878" ;
        thkoeln:artikelnummer     "2101" ;
        thkoeln:dokumententyp     "Wissenschaftlicher Artikel" ;
        thkoeln:peerReviewed      "true" ;
        thkoeln:sprache           "englisch" ;
        thkoeln:status            "validiert" ;
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                <https://fis.th-koeln.de/vivo/individual/FF_001> ;
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                <https://fis.th-koeln.de/vivo/individual/10000159> ;
        <http://cris.nrw/hisinone/hatRessourceart>
                <http://cris.nrw/hisinone/RessourceText> ;
        <http://cris.nrw/hisinone/hatZitat>
                <https://fis.th-koeln.de/vivo/individual/cite_21423-2> , <https://fis.th-koeln.de/vivo/individual/cite_21423-0> , <https://fis.th-koeln.de/vivo/individual/cite_21423-1> ;
        <http://cris.nrw/hisinone/hatZugangsrecht>
                <http://cris.nrw/hisinone/OpenAccess> ;
        <http://purl.org/dc/elements/1.1/date>
                "2026-05-23T18:42:57"^^xsd:dateTime ;
        <http://purl.org/dc/elements/1.1/publisher>
                <https://fis.th-koeln.de/vivo> ;
        <http://purl.org/dc/elements/1.1/rights>
                <https://fis.th-koeln.de/vivo/termsOfUse> ;
        bibo:abstract             "Virus-like particles (VLPs) have the potential to become a versatile carrier platform for vaccination against multiple diseases. In the light of short process development timelines and the demand for reliable and robust processes, metabolic modeling of cell culture processes offers great advantages when coupled with a Quality-by-Design (QbD) development approach. A previous work was able to demonstrate the accurate prediction of HEK293F PiggyBac cell concentration as well as VLP titer and metabolite production with a reduced metabolic model. This work presents the reduced metabolic model for a more productive cell line Sleeping Beauty and emphasizes the need for model re-parameterization when the producer cell line changes. The goal of precise prediction for a fed-batch and continuous HEK293 cultivation can, therefore, be achieved. In terms of decision-making for downstream unit operations, a soft sensor for the prediction of main impurities like proteins and DNA was introduced for the first time for the production of lentiviral vectors with several terms describing the release of impurities like DNA and proteins, growth-related protein production, and enzymatic degradation activity associated with cell dissociation in an accurate manner. The additional information can contribute to a more efficient design phase by reducing experimental effort as well as during cultivation with data-based decision-making. With the aid of real-time process data acquisition through process analytical technology (PAT), its predictive power can be enhanced and lead to more reliable processes." ;
        bibo:doi                  "10.3390/pr13072101" ;
        bibo:issue                "7" ;
        bibo:volume               "13" ;
        vitro:mostSpecificType    thkoeln:Journalartikel ;
        vivo:dateTimeValue        <http://cris.nrw/date2025> ;
        vivo:freetextKeyword      "process optimization" , "virus-like particles (VLPs)" , "digital twins (DTs)" , "autonomous operation" , "human immunodeficiency virus (HIV)" , "process control" , "vaccine manufacturing" , "process analytical technology (PAT)" ;
        vivo:hasPublicationVenue  <https://fis.th-koeln.de/vivo/individual/journal_2286> ;
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        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_21423> .

<http://cris.nrw/date2025>
        a       obo:BFO_0000003 , obo:BFO_0000008 , obo:BFO_0000001 , vivo:DateTimeValue , obo:BFO_0000148 , owl:Thing .

<https://fis.th-koeln.de/vivo/individual/journal_2286>
        a                         thkoeln:Zeitschrift , obo:BFO_0000031 , obo:BFO_0000001 , obo:BFO_0000002 , obo:IAO_0000030 , bibo:Periodical , bibo:Journal , owl:Thing , bibo:Collection ;
        rdfs:label                "Processes" ;
        vivo:publicationVenueFor  <https://fis.th-koeln.de/vivo/individual/publ_21423> .

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        rdfs:label  "Publikationen"@de-DE , "Publications"@en-US .

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        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
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