@prefix ocrer: . @prefix owl: . @prefix scires: . @prefix xsd: . @prefix skos: . @prefix rdfs: . @prefix ocresd: . @prefix swo: . @prefix cito: . @prefix geo: . @prefix ocresst: . @prefix dcterms: . @prefix vivo: . @prefix event: . @prefix vann: . @prefix foaf: . @prefix c4o: . @prefix fabio: . @prefix vcard: . @prefix thkoeln: . @prefix vitro: . @prefix vitro-public: . @prefix rdf: . @prefix ocresp: . @prefix bibo: . @prefix obo: . @prefix ro: . obo:BFO_0000031 a owl:Class ; rdfs:label "Bedingter Kontinuant"@de-DE , "Generically Dependent Continuant"@en-US , "Generically Dependent Continuant"@en . . a thkoeln:Zitat , owl:Thing . a , owl:NamedIndividual , owl:Thing ; rdfs:label "Open Access"@en-US , "Open Access"@de-DE . obo:BFO_0000002 a owl:Class ; rdfs:label "Kontinuant"@de-DE , "Continuant"@en-US , "Continuant"@en . a thkoeln:Organisationseinheit , foaf:Agent , obo:BFO_0000001 , obo:BFO_0000004 , obo:BFO_0000002 , foaf:Organization , owl:Thing ; rdfs:label "Fakultät für Angewandte Naturwissenschaften" ; . a owl:Thing , obo:BFO_0000001 , bibo:Collection , bibo:Periodical , obo:BFO_0000031 , obo:IAO_0000030 , obo:BFO_0000002 , thkoeln:Zeitschrift , bibo:Journal ; rdfs:label "Bioorganic & medicinal chemistry letters" ; vivo:publicationVenueFor . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . thkoeln:Artikel a owl:Class ; rdfs:label "Artikel"@de-DE , "Article"@en-US . a obo:BFO_0000003 , obo:BFO_0000008 , obo:BFO_0000001 , vivo:DateTimeValue , obo:BFO_0000148 , owl:Thing . obo:BFO_0000001 a owl:Class ; rdfs:label "Entität"@de-DE , "Entity"@en-US , "Entity"@en . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . a owl:NamedIndividual , , owl:Thing ; rdfs:label "Text"@de-DE , "Text"@en-US . bibo:Document a owl:Class ; rdfs:label "Dokument"@de-DE , "Document"@en-US , "Document"@en . owl:Thing a owl:Class . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . thkoeln:Journalartikel a owl:Class ; rdfs:label "Journal Article"@en-US , "Journalartikel"@de-DE . obo:IAO_0000030 a owl:Class ; rdfs:label "Entität für Informationsinhalt"@de-DE , "Information Content Entity"@en-US , "Information Content Entity"@en . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . a thkoeln:Zitat , owl:Thing . a thkoeln:Zitat , owl:Thing . thkoeln:Publikation a owl:Class ; rdfs:label "Publikationen"@de-DE , "Publications"@en-US . a owl:Thing , obo:BFO_0000002 , obo:BFO_0000031 , thkoeln:Artikel , obo:BFO_0000001 , thkoeln:Publikation , bibo:Document , obo:IAO_0000030 , thkoeln:Journalartikel , foaf:Document ; rdfs:label "Tissue Transglutaminase" , "RDF description of Tissue Transglutaminase - https://fis.th-koeln.de/vivo/individual/publ_20461" ; thkoeln:abstractDE "Tissue transglutaminase (transglutaminase 2) is a multifunctional enzyme with many interesting properties resulting in versatile roles in both physiology and pathophysiology. Herein, the particular involvement of the enzyme in human diseases will be outlined with special emphasis on its role in cancer and in tissue interactions with biomaterials. Despite recent progress in unraveling the different cellular functions of transglutaminase 2, several questions remain. Transglutaminase 2 features in both confirmed and some still ambiguous roles within pathological conditions, raising interest in developing inhibitors and imaging probes which target this enzyme. One important prerequisite for identifying and characterizing such molecular tools are reliable assay methods to measure the enzymatic activity. This digest Letter will provide clarification about the various assay methods described to date, accompanied by a discussion of recent progress in the development of inhibitors and imaging probes targeting transglutaminase 2. © 2013 Elsevier Ltd. All rights reserved." ; thkoeln:dokumententyp "Wissenschaftlicher Artikel" ; thkoeln:peerReviewed "true" ; thkoeln:sprache "englisch" ; thkoeln:status "validiert" ; thkoeln:subtitle "An Emerging Target for Therapy and Imaging" ; ; ; ; , , ; ; "2026-04-04T03:11:36"^^xsd:dateTime ; ; ; bibo:abstract "Tissue transglutaminase (transglutaminase 2) is a multifunctional enzyme with many interesting properties resulting in versatile roles in both physiology and pathophysiology. Herein, the particular involvement of the enzyme in human diseases will be outlined with special emphasis on its role in cancer and in tissue interactions with biomaterials. Despite recent progress in unraveling the different cellular functions of transglutaminase 2, several questions remain. Transglutaminase 2 features in both confirmed and some still ambiguous roles within pathological conditions, raising interest in developing inhibitors and imaging probes which target this enzyme. One important prerequisite for identifying and characterizing such molecular tools are reliable assay methods to measure the enzymatic activity. This digest Letter will provide clarification about the various assay methods described to date, accompanied by a discussion of recent progress in the development of inhibitors and imaging probes targeting transglutaminase 2. © 2013 Elsevier Ltd. All rights reserved." ; bibo:doi "10.1016/j.bmcl.2013.09.060" ; bibo:issue "24" ; bibo:pageEnd "6543" ; bibo:pageStart "6528" ; bibo:volume "23" ; vitro:mostSpecificType thkoeln:Journalartikel ; vivo:dateTimeValue ; vivo:freetextKeyword "Tissue Transglutaminase (TGase 2)" , "Imaging Probes" , "Biomaterial-Tissue Interface" , "Activity Assays" , "Inhibitors" , "Cancer" ; vivo:hasPublicationVenue ; vivo:relatedBy , , , .