Journalartikel - Wissenschaftlicher Artikel | 2016 | Peer reviewed

A Synthetic Glycopeptide Vaccine for the Induction of a Monoclonal Antibody that Differentiates Between Normal and Tumor Mammary Cells and Enables the Diagnosis of Human Pancreatic Cancer

Autor*innen

Palitzsch, Bjorn ; Gaidzik, Nikola ; Stergiou, Natascha ; Stahn, Sonja ; Hartmann, Sebastian ; Gerlitzki, Bastian ; Teusch, Nicole ; Flemming, Peer ; Schmitt, Edgar ; Kunz, Horst

Zeitschrift

Angewandte Chemie

DOI

10.1002/anie.201509935

Weitere Details

Sprache

englisch

Darstellungsform

Text

Band

Ausgabe

Seitenbereich

2894 - 2898

In studies within the realm of cancer immunotherapy, the synthesis of exactly specified tumor-associated glycopeptide antigens is shown to be a key strategy for obtaining a highly selective biological reagent, that is, a monoclonal antibody that completely differentiates between tumor and normal epithelial cells and specifically marks the tumor cells in pancreas tumors. Mucin MUC1, which is overexpressed in many prevalent cancers, was identified as a promising target for this strategy. Tumor-associated MUC1 differs significantly from that expressed by normal cells, in particular by altered glycosylation. Structurally defined tumor-associated MUC1 cannot be isolated from tumor cells. We synthesized MUC1-glycopeptide vaccines and analyzed their structure-activity relationships in immunizations; a monoclonal antibody that specifically distinguishes between human normal and tumor epithelial cells was thus generated.

Zitierstile

Palitzsch, B., Gaidzik, N., Stergiou, N., Stahn, S., Hartmann, S., Gerlitzki, B., … Kunz, H. (2016). A Synthetic Glycopeptide Vaccine for the Induction of a Monoclonal Antibody that Differentiates Between Normal and Tumor Mammary Cells and Enables the Diagnosis of Human Pancreatic Cancer. Angewandte Chemie, 55(8), 2894–2898. doi:10.1002/anie.201509935

In die Zwischenablage kopieren

Palitzsch, B., Gaidzik, N., Stergiou, N., Stahn, S., Hartmann, S., Gerlitzki, B., Teusch, N., Flemming, P., Schmitt, E. and Kunz, H., 2016. A Synthetic Glycopeptide Vaccine for the Induction of a Monoclonal Antibody that Differentiates Between Normal and Tumor Mammary Cells and Enables the Diagnosis of Human Pancreatic Cancer. Angewandte Chemie, 55(8), pp.2894–2898.

In die Zwischenablage kopieren

Palitzsch, Bjorn u. a. 2016. A Synthetic Glycopeptide Vaccine for the Induction of a Monoclonal Antibody that Differentiates Between Normal and Tumor Mammary Cells and Enables the Diagnosis of Human Pancreatic Cancer. Angewandte Chemie 55, 8, 2894–2898.

American Psychological Association 6th edition (DOI)

Anglia Ruskin University - Harvard

Gesellschaft für Bildung und Forschung in Europa - Harvard