@prefix ocrer: <http://purl.org/net/OCRe/research.owl#> .
@prefix owl:   <http://www.w3.org/2002/07/owl#> .
@prefix scires: <http://vivoweb.org/ontology/scientific-research#> .
@prefix xsd:   <http://www.w3.org/2001/XMLSchema#> .
@prefix skos:  <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs:  <http://www.w3.org/2000/01/rdf-schema#> .
@prefix ocresd: <http://purl.org/net/OCRe/study_design.owl#> .
@prefix swo:   <http://www.ebi.ac.uk/efo/swo/> .
@prefix cito:  <http://purl.org/spar/cito/> .
@prefix geo:   <http://aims.fao.org/aos/geopolitical.owl#> .
@prefix ocresst: <http://purl.org/net/OCRe/statistics.owl#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix vivo:  <http://vivoweb.org/ontology/core#> .
@prefix event: <http://purl.org/NET/c4dm/event.owl#> .
@prefix vann:  <http://purl.org/vocab/vann/> .
@prefix foaf:  <http://xmlns.com/foaf/0.1/> .
@prefix c4o:   <http://purl.org/spar/c4o/> .
@prefix fabio: <http://purl.org/spar/fabio/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix thkoeln: <http://cris.nrw/hisinone#> .
@prefix vitro: <http://vitro.mannlib.cornell.edu/ns/vitro/0.7#> .
@prefix vitro-public: <http://vitro.mannlib.cornell.edu/ns/vitro/public#> .
@prefix rdf:   <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix ocresp: <http://purl.org/net/OCRe/study_protocol.owl#> .
@prefix bibo:  <http://purl.org/ontology/bibo/> .
@prefix obo:   <http://purl.obolibrary.org/obo/> .
@prefix ro:    <http://purl.obolibrary.org/obo/ro.owl#> .

obo:BFO_0000031  a  owl:Class ;
        rdfs:label  "Bedingter Kontinuant"@de-DE , "Generically Dependent Continuant"@en-US , "Generically Dependent Continuant"@en .

<https://fis.th-koeln.de/vivo/individual/FF_001>
        <http://cris.nrw/hisinone/istForschungsfeldvon>
                <https://fis.th-koeln.de/vivo/individual/publ_16796> .

<https://fis.th-koeln.de/vivo/individual/aut_16796-1>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_16796> .

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        a           <http://cris.nrw/hisinone/Zugangsrecht> , owl:NamedIndividual , owl:Thing ;
        rdfs:label  "Open Access"@en-US , "Open Access"@de-DE .

<https://fis.th-koeln.de/vivo/individual/cite_16796-2>
        a       thkoeln:Zitat , owl:Thing .

obo:BFO_0000002  a  owl:Class ;
        rdfs:label  "Kontinuant"@de-DE , "Continuant"@en-US , "Continuant"@en .

thkoeln:Artikel  a  owl:Class ;
        rdfs:label  "Artikel"@de-DE , "Article"@en-US .

<https://fis.th-koeln.de/vivo/individual/cite_16796-1>
        a       thkoeln:Zitat , owl:Thing .

obo:BFO_0000001  a  owl:Class ;
        rdfs:label  "Entität"@de-DE , "Entity"@en-US , "Entity"@en .

<http://cris.nrw/hisinone/RessourceText>
        a           owl:NamedIndividual , <http://cris.nrw/hisinone/ArtderRessource> , owl:Thing ;
        rdfs:label  "Text"@de-DE , "Text"@en-US .

bibo:Document  a    owl:Class ;
        rdfs:label  "Dokument"@de-DE , "Document"@en-US , "Document"@en .

<https://fis.th-koeln.de/vivo/individual/cite_16796-0>
        a       thkoeln:Zitat , owl:Thing .

owl:Thing  a    owl:Class .

thkoeln:Journalartikel
        a           owl:Class ;
        rdfs:label  "Journal Article"@en-US , "Journalartikel"@de-DE .

<https://fis.th-koeln.de/vivo/individual/aut_16796-4>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_16796> .

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        rdfs:label  "Entität für Informationsinhalt"@de-DE , "Information Content Entity"@en-US , "Information Content Entity"@en .

<http://cris.nrw/date2020>
        a       obo:BFO_0000003 , obo:BFO_0000008 , obo:BFO_0000001 , vivo:DateTimeValue , obo:BFO_0000148 , owl:Thing .

<https://fis.th-koeln.de/vivo/individual/journal_2262>
        a                         obo:BFO_0000002 , obo:IAO_0000030 , thkoeln:Zeitschrift , bibo:Periodical , bibo:Journal , owl:Thing , bibo:Collection , obo:BFO_0000031 , obo:BFO_0000001 ;
        rdfs:label                "eLife" ;
        vivo:publicationVenueFor  <https://fis.th-koeln.de/vivo/individual/publ_16796> .

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        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_16796> .

<https://fis.th-koeln.de/vivo/individual/aut_16796-2>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_16796> .

thkoeln:Publikation  a  owl:Class ;
        rdfs:label  "Publikationen"@de-DE , "Publications"@en-US .

<https://fis.th-koeln.de/vivo/individual/10000126>
        a           thkoeln:Organisationseinheit , foaf:Agent , obo:BFO_0000001 , obo:BFO_0000004 , obo:BFO_0000002 , foaf:Organization , owl:Thing ;
        rdfs:label  "Institut für Informationswissenschaft" ;
        <http://cris.nrw/hisinone/istOrganisationseinheitVon>
                <https://fis.th-koeln.de/vivo/individual/publ_16796> .

<https://fis.th-koeln.de/vivo/individual/publ_16796>
        a                         obo:BFO_0000002 , thkoeln:Journalartikel , obo:BFO_0000001 , bibo:Document , thkoeln:Publikation , obo:IAO_0000030 , foaf:Document , obo:BFO_0000031 , thkoeln:Artikel , owl:Thing ;
        rdfs:label                "Gene Autoregulation by 3’ UTR-derived Bacterial Small RNAs" , "RDF description of Gene Autoregulation by 3’ UTR-derived Bacterial Small RNAs - https://fis.th-koeln.de/vivo/individual/publ_16796" ;
        thkoeln:artikelnummer     "e58836" ;
        thkoeln:dokumententyp     "Wissenschaftlicher Artikel" ;
        thkoeln:peerReviewed      "true" ;
        thkoeln:sprache           "englisch" ;
        thkoeln:status            "validiert" ;
        <http://cris.nrw/hisinone/hatForschungsfeld>
                <https://fis.th-koeln.de/vivo/individual/FF_001> ;
        <http://cris.nrw/hisinone/hatOrganisationseinheit>
                <https://fis.th-koeln.de/vivo/individual/10000126> ;
        <http://cris.nrw/hisinone/hatRessourceart>
                <http://cris.nrw/hisinone/RessourceText> ;
        <http://cris.nrw/hisinone/hatZitat>
                <https://fis.th-koeln.de/vivo/individual/cite_16796-0> , <https://fis.th-koeln.de/vivo/individual/cite_16796-2> , <https://fis.th-koeln.de/vivo/individual/cite_16796-1> ;
        <http://cris.nrw/hisinone/hatZugangsrecht>
                <http://cris.nrw/hisinone/OpenAccess> ;
        <http://purl.org/dc/elements/1.1/date>
                "2026-04-03T23:49:20"^^xsd:dateTime ;
        <http://purl.org/dc/elements/1.1/publisher>
                <https://fis.th-koeln.de/vivo> ;
        <http://purl.org/dc/elements/1.1/rights>
                <https://fis.th-koeln.de/vivo/termsOfUse> ;
        bibo:abstract             "Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known to biology. Frequently reported for transcriptional regulators, negative feedback control relies on binding of a transcription factor to its own promoter. Here, we report a novel mechanism for gene autoregulation in bacteria relying on small regulatory RNA (sRNA) and the major endoribonuclease, RNase E. TIER-seq analysis (transiently-inactivating-an-endoribonuclease-followed-by-RNA-seq) revealed ~25,000 RNase E-dependent cleavage sites in Vibrio cholerae, several of which resulted in the accumulation of stable sRNAs. Focusing on two examples, OppZ and CarZ, we discovered that these sRNAs are processed from the 3’ untranslated region (3’ UTR) of the oppABCDF and carAB operons, respectively, and base-pair with their own transcripts to inhibit translation. For OppZ, this process also triggers Rho-dependent transcription termination. Our data show that sRNAs from 3’ UTRs serve as autoregulatory elements allowing negative feedback control at the post-transcriptional level." ;
        bibo:doi                  "10.7554/eLife.58836" ;
        bibo:volume               "9" ;
        vitro:mostSpecificType    thkoeln:Journalartikel ;
        vivo:dateTimeValue        <http://cris.nrw/date2020> ;
        vivo:freetextKeyword      "Vibrio cholerae" , "small RNA" , "Hfq" , "autoregulation" , "RNase E" ;
        vivo:hasPublicationVenue  <https://fis.th-koeln.de/vivo/individual/journal_2262> ;
        vivo:relatedBy            <https://fis.th-koeln.de/vivo/individual/aut_16796-1> , <https://fis.th-koeln.de/vivo/individual/aut_16796-2> , <https://fis.th-koeln.de/vivo/individual/aut_16796-3> , <https://fis.th-koeln.de/vivo/individual/aut_16796-4> .