@prefix ocrer: <http://purl.org/net/OCRe/research.owl#> .
@prefix owl:   <http://www.w3.org/2002/07/owl#> .
@prefix scires: <http://vivoweb.org/ontology/scientific-research#> .
@prefix xsd:   <http://www.w3.org/2001/XMLSchema#> .
@prefix skos:  <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs:  <http://www.w3.org/2000/01/rdf-schema#> .
@prefix ocresd: <http://purl.org/net/OCRe/study_design.owl#> .
@prefix swo:   <http://www.ebi.ac.uk/efo/swo/> .
@prefix cito:  <http://purl.org/spar/cito/> .
@prefix geo:   <http://aims.fao.org/aos/geopolitical.owl#> .
@prefix ocresst: <http://purl.org/net/OCRe/statistics.owl#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix vivo:  <http://vivoweb.org/ontology/core#> .
@prefix event: <http://purl.org/NET/c4dm/event.owl#> .
@prefix vann:  <http://purl.org/vocab/vann/> .
@prefix foaf:  <http://xmlns.com/foaf/0.1/> .
@prefix c4o:   <http://purl.org/spar/c4o/> .
@prefix fabio: <http://purl.org/spar/fabio/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix thkoeln: <http://cris.nrw/hisinone#> .
@prefix vitro: <http://vitro.mannlib.cornell.edu/ns/vitro/0.7#> .
@prefix vitro-public: <http://vitro.mannlib.cornell.edu/ns/vitro/public#> .
@prefix rdf:   <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix ocresp: <http://purl.org/net/OCRe/study_protocol.owl#> .
@prefix bibo:  <http://purl.org/ontology/bibo/> .
@prefix obo:   <http://purl.obolibrary.org/obo/> .
@prefix ro:    <http://purl.obolibrary.org/obo/ro.owl#> .

obo:BFO_0000031  a  owl:Class ;
        rdfs:label  "Bedingter Kontinuant"@de-DE , "Generically Dependent Continuant"@en-US , "Generically Dependent Continuant"@en .

<https://fis.th-koeln.de/vivo/individual/FF_001>
        <http://cris.nrw/hisinone/istForschungsfeldvon>
                <https://fis.th-koeln.de/vivo/individual/publ_14385> .

<http://cris.nrw/hisinone/OpenAccess>
        a           <http://cris.nrw/hisinone/Zugangsrecht> , owl:NamedIndividual , owl:Thing ;
        rdfs:label  "Open Access"@en-US , "Open Access"@de-DE .

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        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14385> .

obo:BFO_0000002  a  owl:Class ;
        rdfs:label  "Kontinuant"@de-DE , "Continuant"@en-US , "Continuant"@en .

<https://fis.th-koeln.de/vivo/individual/10000159>
        a           thkoeln:Organisationseinheit , foaf:Agent , obo:BFO_0000001 , obo:BFO_0000004 , obo:BFO_0000002 , foaf:Organization , owl:Thing ;
        rdfs:label  "Fakultät für Angewandte Naturwissenschaften" ;
        <http://cris.nrw/hisinone/istOrganisationseinheitVon>
                <https://fis.th-koeln.de/vivo/individual/publ_14385> .

thkoeln:Artikel  a  owl:Class ;
        rdfs:label  "Artikel"@de-DE , "Article"@en-US .

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        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14385> .

obo:BFO_0000001  a  owl:Class ;
        rdfs:label  "Entität"@de-DE , "Entity"@en-US , "Entity"@en .

<http://cris.nrw/hisinone/RessourceText>
        a           owl:NamedIndividual , <http://cris.nrw/hisinone/ArtderRessource> , owl:Thing ;
        rdfs:label  "Text"@de-DE , "Text"@en-US .

bibo:Document  a    owl:Class ;
        rdfs:label  "Dokument"@de-DE , "Document"@en-US , "Document"@en .

<https://fis.th-koeln.de/vivo/individual/publ_14385>
        a                         owl:Thing , obo:BFO_0000001 , thkoeln:Artikel , foaf:Document , thkoeln:Journalartikel , thkoeln:Publikation , bibo:Document , obo:BFO_0000002 , obo:BFO_0000031 , obo:IAO_0000030 ;
        rdfs:label                "RDF description of Fusoselect: Cell-cell fusion activity engineered by directed evolution of a retroviral glycoprotein - https://fis.th-koeln.de/vivo/individual/publ_14385" , "Fusoselect: Cell-cell fusion activity engineered by directed evolution of a retroviral glycoprotein" ;
        thkoeln:URL               "http://www.scopus.com/inward/record.url?eid=2-s2.0-33645528964&partnerID=MN8TOARS" ;
        thkoeln:artikelnummer     "e41" ;
        thkoeln:dokumententyp     "Wissenschaftlicher Artikel" ;
        thkoeln:peerReviewed      "true" ;
        thkoeln:sprache           "englisch" ;
        thkoeln:status            "validiert" ;
        <http://cris.nrw/hisinone/hatForschungsfeld>
                <https://fis.th-koeln.de/vivo/individual/FF_001> ;
        <http://cris.nrw/hisinone/hatOrganisationseinheit>
                <https://fis.th-koeln.de/vivo/individual/10000159> ;
        <http://cris.nrw/hisinone/hatRessourceart>
                <http://cris.nrw/hisinone/RessourceText> ;
        <http://cris.nrw/hisinone/hatZitat>
                <https://fis.th-koeln.de/vivo/individual/cite_14385-1> , <https://fis.th-koeln.de/vivo/individual/cite_14385-2> , <https://fis.th-koeln.de/vivo/individual/cite_14385-0> ;
        <http://cris.nrw/hisinone/hatZugangsrecht>
                <http://cris.nrw/hisinone/OpenAccess> ;
        <http://purl.org/dc/elements/1.1/date>
                "2026-04-04T01:33:53"^^xsd:dateTime ;
        <http://purl.org/dc/elements/1.1/publisher>
                <https://fis.th-koeln.de/vivo> ;
        <http://purl.org/dc/elements/1.1/rights>
                <https://fis.th-koeln.de/vivo/termsOfUse> ;
        bibo:abstract             "Membrane fusion plays a key role in many biological processes including vesicle trafficking, synaptic transmission, fertilization or cell entry of enveloped viruses. As a common feature the fusion process is mediated by distinct membrane proteins. We describe here ‘Fusoselect’, a universal procedure allowing the identification and engineering of molecular determinants for cell–cell fusion-activity by directed evolution. The system couples cell–cell fusion with the release of retroviral particles, but can principally be applied to membrane proteins of non-viral origin as well. As a model system, we chose a γ-retroviral envelope protein, which naturally becomes fusion-active through proteolytic processing by the viral protease. The selection process evolved variants that, in contrast to the parental protein, mediated cell–cell fusion in absence of the viral protease. Detailed analysis of the variants revealed molecular determinants for fusion competence in the cytoplasmic tail (CT) of retroviral Env proteins and demonstrated the power of Fusoselect." ;
        bibo:doi                  "10.1093/nar/gkl053" ;
        bibo:issue                "5" ;
        bibo:volume               "34" ;
        vitro:mostSpecificType    thkoeln:Journalartikel ;
        vivo:dateTimeValue        <http://cris.nrw/date2006> ;
        vivo:hasPublicationVenue  <https://fis.th-koeln.de/vivo/individual/journal_2801> ;
        vivo:relatedBy            <https://fis.th-koeln.de/vivo/individual/aut_14385-3> , <https://fis.th-koeln.de/vivo/individual/aut_14385-5> , <https://fis.th-koeln.de/vivo/individual/aut_14385-6> , <https://fis.th-koeln.de/vivo/individual/aut_14385-2> , <https://fis.th-koeln.de/vivo/individual/aut_14385-1> , <https://fis.th-koeln.de/vivo/individual/aut_14385-4> .

<https://fis.th-koeln.de/vivo/individual/aut_14385-5>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14385> .

owl:Thing  a    owl:Class .

<https://fis.th-koeln.de/vivo/individual/cite_14385-2>
        a       thkoeln:Zitat , owl:Thing .

thkoeln:Journalartikel
        a           owl:Class ;
        rdfs:label  "Journal Article"@en-US , "Journalartikel"@de-DE .

obo:IAO_0000030  a  owl:Class ;
        rdfs:label  "Entität für Informationsinhalt"@de-DE , "Information Content Entity"@en-US , "Information Content Entity"@en .

<https://fis.th-koeln.de/vivo/individual/aut_14385-4>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14385> .

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        a       thkoeln:Zitat , owl:Thing .

<https://fis.th-koeln.de/vivo/individual/journal_2801>
        a                         thkoeln:Zeitschrift , owl:Thing , obo:BFO_0000002 , bibo:Collection , bibo:Journal , obo:BFO_0000001 , obo:BFO_0000031 , bibo:Periodical , obo:IAO_0000030 ;
        rdfs:label                "Nucleic acids research" ;
        vivo:publicationVenueFor  <https://fis.th-koeln.de/vivo/individual/publ_14385> .

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        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14385> .

<https://fis.th-koeln.de/vivo/individual/cite_14385-0>
        a       thkoeln:Zitat , owl:Thing .

<http://cris.nrw/date2006>
        a       obo:BFO_0000003 , obo:BFO_0000008 , obo:BFO_0000001 , vivo:DateTimeValue , obo:BFO_0000148 , owl:Thing .

thkoeln:Publikation  a  owl:Class ;
        rdfs:label  "Publikationen"@de-DE , "Publications"@en-US .

<https://fis.th-koeln.de/vivo/individual/aut_14385-2>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14385> .