@prefix ocrer: <http://purl.org/net/OCRe/research.owl#> .
@prefix owl:   <http://www.w3.org/2002/07/owl#> .
@prefix scires: <http://vivoweb.org/ontology/scientific-research#> .
@prefix xsd:   <http://www.w3.org/2001/XMLSchema#> .
@prefix skos:  <http://www.w3.org/2004/02/skos/core#> .
@prefix rdfs:  <http://www.w3.org/2000/01/rdf-schema#> .
@prefix ocresd: <http://purl.org/net/OCRe/study_design.owl#> .
@prefix swo:   <http://www.ebi.ac.uk/efo/swo/> .
@prefix cito:  <http://purl.org/spar/cito/> .
@prefix geo:   <http://aims.fao.org/aos/geopolitical.owl#> .
@prefix ocresst: <http://purl.org/net/OCRe/statistics.owl#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix vivo:  <http://vivoweb.org/ontology/core#> .
@prefix event: <http://purl.org/NET/c4dm/event.owl#> .
@prefix vann:  <http://purl.org/vocab/vann/> .
@prefix foaf:  <http://xmlns.com/foaf/0.1/> .
@prefix c4o:   <http://purl.org/spar/c4o/> .
@prefix fabio: <http://purl.org/spar/fabio/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix thkoeln: <http://cris.nrw/hisinone#> .
@prefix vitro: <http://vitro.mannlib.cornell.edu/ns/vitro/0.7#> .
@prefix vitro-public: <http://vitro.mannlib.cornell.edu/ns/vitro/public#> .
@prefix rdf:   <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix ocresp: <http://purl.org/net/OCRe/study_protocol.owl#> .
@prefix bibo:  <http://purl.org/ontology/bibo/> .
@prefix obo:   <http://purl.obolibrary.org/obo/> .
@prefix ro:    <http://purl.obolibrary.org/obo/ro.owl#> .

<https://fis.th-koeln.de/vivo/individual/FF_001>
        <http://cris.nrw/hisinone/istForschungsfeldvon>
                <https://fis.th-koeln.de/vivo/individual/publ_14024> .

<https://fis.th-koeln.de/vivo/individual/journal_2139>
        a                         obo:BFO_0000001 , bibo:Periodical , bibo:Journal , obo:IAO_0000030 , obo:BFO_0000002 , bibo:Collection , owl:Thing , obo:BFO_0000031 , thkoeln:Zeitschrift ;
        rdfs:label                "Viruses" ;
        vivo:publicationVenueFor  <https://fis.th-koeln.de/vivo/individual/publ_14024> .

<http://cris.nrw/hisinone/OpenAccess>
        a           <http://cris.nrw/hisinone/Zugangsrecht> , owl:NamedIndividual , owl:Thing ;
        rdfs:label  "Open Access"@en-US , "Open Access"@de-DE .

obo:BFO_0000002  a  owl:Class ;
        rdfs:label  "Kontinuant"@de-DE , "Continuant"@en-US , "Continuant"@en .

<https://fis.th-koeln.de/vivo/individual/aut_14024-3>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14024> .

thkoeln:Artikel  a  owl:Class ;
        rdfs:label  "Artikel"@de-DE , "Article"@en-US .

<http://cris.nrw/date2022>
        a       obo:BFO_0000003 , obo:BFO_0000008 , obo:BFO_0000001 , vivo:DateTimeValue , obo:BFO_0000148 , owl:Thing .

obo:BFO_0000001  a  owl:Class ;
        rdfs:label  "Entität"@de-DE , "Entity"@en-US , "Entity"@en .

<https://fis.th-koeln.de/vivo/individual/aut_14024-2>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14024> .

<http://cris.nrw/hisinone/RessourceText>
        a           owl:NamedIndividual , <http://cris.nrw/hisinone/ArtderRessource> , owl:Thing ;
        rdfs:label  "Text"@de-DE , "Text"@en-US .

bibo:Document  a    owl:Class ;
        rdfs:label  "Dokument"@de-DE , "Document"@en-US , "Document"@en .

owl:Thing  a    owl:Class .

<https://fis.th-koeln.de/vivo/individual/aut_14024-1>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14024> .

<https://fis.th-koeln.de/vivo/individual/aut_14024-7>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14024> .

thkoeln:Journalartikel
        a           owl:Class ;
        rdfs:label  "Journal Article"@en-US , "Journalartikel"@de-DE .

<https://fis.th-koeln.de/vivo/individual/cite_14024-2>
        a       thkoeln:Zitat , owl:Thing .

obo:IAO_0000030  a  owl:Class ;
        rdfs:label  "Entität für Informationsinhalt"@de-DE , "Information Content Entity"@en-US , "Information Content Entity"@en .

<https://fis.th-koeln.de/vivo/individual/publ_14024>
        a                         obo:IAO_0000030 , foaf:Document , thkoeln:Journalartikel , thkoeln:Publikation , obo:BFO_0000002 , thkoeln:Artikel , obo:BFO_0000001 , bibo:Document , obo:BFO_0000031 , owl:Thing ;
        rdfs:label                "RDF description of Dual-RNAseq Analysis Unravels Virus-Host Interactions of MetSV and Methanosarcina mazei - https://fis.th-koeln.de/vivo/individual/publ_14024" , "Dual-RNAseq Analysis Unravels Virus-Host Interactions of MetSV and Methanosarcina mazei" ;
        thkoeln:URL               "https://www.mdpi.com/1999-4915/14/11/2585/pdf?version=1669116945" ;
        thkoeln:artikelnummer     "2585" ;
        thkoeln:dokumententyp     "Wissenschaftlicher Artikel" ;
        thkoeln:peerReviewed      "true" ;
        thkoeln:sprache           "englisch" ;
        thkoeln:status            "validiert" ;
        <http://cris.nrw/hisinone/hatForschungsfeld>
                <https://fis.th-koeln.de/vivo/individual/FF_001> ;
        <http://cris.nrw/hisinone/hatOrganisationseinheit>
                <https://fis.th-koeln.de/vivo/individual/10000126> ;
        <http://cris.nrw/hisinone/hatRessourceart>
                <http://cris.nrw/hisinone/RessourceText> ;
        <http://cris.nrw/hisinone/hatZitat>
                <https://fis.th-koeln.de/vivo/individual/cite_14024-0> , <https://fis.th-koeln.de/vivo/individual/cite_14024-2> , <https://fis.th-koeln.de/vivo/individual/cite_14024-1> ;
        <http://cris.nrw/hisinone/hatZugangsrecht>
                <http://cris.nrw/hisinone/OpenAccess> ;
        <http://purl.org/dc/elements/1.1/date>
                "2026-04-04T00:08:11"^^xsd:dateTime ;
        <http://purl.org/dc/elements/1.1/publisher>
                <https://fis.th-koeln.de/vivo> ;
        <http://purl.org/dc/elements/1.1/rights>
                <https://fis.th-koeln.de/vivo/termsOfUse> ;
        bibo:abstract             "Methanosarcina spherical virus (MetSV), infecting Methanosarcina species, encodes 22 genes, but their role in the infection process in combination with host genes has remained unknown. To study the infection process in detail, infected and uninfected M. mazei cultures were compared using dual-RNAseq, qRT-PCRs, and transmission electron microscopy (TEM). The transcriptome analysis strongly indicates a combined role of virus and host genes in replication, virus assembly, and lysis. Thereby, 285 host and virus genes were significantly regulated. Within these 285 regulated genes, a network of the viral polymerase, MetSVORF6, MetSVORF5, MetSVORF2, and the host genes encoding NrdD, NrdG, a CDC48 family protein, and a SSB protein with a role in viral replication was postulated. Ultrastructural analysis at 180 min p.i. revealed many infected cells with virus particles randomly scattered throughout the cytoplasm or attached at the cell surface, and membrane fragments indicating cell lysis. Dual-RNAseq and qRT-PCR analyses suggested a multifactorial lysis reaction in potential connection to the regulation of a cysteine proteinase, a pirin-like protein and a HicB-solo protein. Our study's results led to the first preliminary infection model of MetSV infecting M. mazei, summarizing the key infection steps as follows: replication, assembly, and host cell lysis." ;
        bibo:doi                  "10.3390/v14112585" ;
        bibo:issue                "11" ;
        bibo:volume               "14" ;
        vitro:mostSpecificType    thkoeln:Journalartikel ;
        vivo:dateTimeValue        <http://cris.nrw/date2022> ;
        vivo:freetextKeyword      "Lysis" , "Virus–host Interaction" , "Archaea" , "Dual-RNAseq" , "Replication" , "MetSV" , "Methanosarcina" ;
        vivo:hasPublicationVenue  <https://fis.th-koeln.de/vivo/individual/journal_2139> ;
        vivo:relatedBy            <https://fis.th-koeln.de/vivo/individual/aut_14024-6> , <https://fis.th-koeln.de/vivo/individual/aut_14024-4> , <https://fis.th-koeln.de/vivo/individual/aut_14024-1> , <https://fis.th-koeln.de/vivo/individual/aut_14024-7> , <https://fis.th-koeln.de/vivo/individual/aut_14024-5> , <https://fis.th-koeln.de/vivo/individual/aut_14024-2> , <https://fis.th-koeln.de/vivo/individual/aut_14024-3> .

<https://fis.th-koeln.de/vivo/individual/aut_14024-6>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14024> .

<https://fis.th-koeln.de/vivo/individual/cite_14024-1>
        a       thkoeln:Zitat , owl:Thing .

<https://fis.th-koeln.de/vivo/individual/aut_14024-5>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14024> .

<https://fis.th-koeln.de/vivo/individual/cite_14024-0>
        a       thkoeln:Zitat , owl:Thing .

thkoeln:Publikation  a  owl:Class ;
        rdfs:label  "Publikationen"@de-DE , "Publications"@en-US .

<https://fis.th-koeln.de/vivo/individual/10000126>
        a           thkoeln:Organisationseinheit , foaf:Agent , obo:BFO_0000001 , obo:BFO_0000004 , obo:BFO_0000002 , foaf:Organization , owl:Thing ;
        rdfs:label  "Institut für Informationswissenschaft" ;
        <http://cris.nrw/hisinone/istOrganisationseinheitVon>
                <https://fis.th-koeln.de/vivo/individual/publ_14024> .

<https://fis.th-koeln.de/vivo/individual/aut_14024-4>
        a             obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ;
        vivo:relates  <https://fis.th-koeln.de/vivo/individual/publ_14024> .

obo:BFO_0000031  a  owl:Class ;
        rdfs:label  "Bedingter Kontinuant"@de-DE , "Generically Dependent Continuant"@en-US , "Generically Dependent Continuant"@en .