@prefix ocrer: . @prefix owl: . @prefix scires: . @prefix xsd: . @prefix skos: . @prefix rdfs: . @prefix ocresd: . @prefix swo: . @prefix cito: . @prefix geo: . @prefix ocresst: . @prefix dcterms: . @prefix vivo: . @prefix event: . @prefix vann: . @prefix foaf: . @prefix c4o: . @prefix fabio: . @prefix vcard: . @prefix thkoeln: . @prefix vitro: . @prefix vitro-public: . @prefix rdf: . @prefix ocresp: . @prefix bibo: . @prefix obo: . @prefix ro: . . a thkoeln:Zitat , owl:Thing . a , owl:NamedIndividual , owl:Thing ; rdfs:label "Open Access"@en-US , "Open Access"@de-DE . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . obo:BFO_0000002 a owl:Class ; rdfs:label "Kontinuant"@de-DE , "Continuant"@en-US , "Continuant"@en . thkoeln:Artikel a owl:Class ; rdfs:label "Artikel"@de-DE , "Article"@en-US . a obo:BFO_0000001 , bibo:Collection , owl:Thing , obo:BFO_0000002 , bibo:Journal , obo:IAO_0000030 , obo:BFO_0000031 , bibo:Periodical , thkoeln:Zeitschrift ; rdfs:label "Brain Sciences" ; vivo:publicationVenueFor . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . obo:BFO_0000001 a owl:Class ; rdfs:label "Entität"@de-DE , "Entity"@en-US , "Entity"@en . a bibo:Document , foaf:Document , thkoeln:Artikel , obo:BFO_0000002 , obo:IAO_0000030 , thkoeln:Publikation , owl:Thing , thkoeln:Journalartikel , obo:BFO_0000001 , obo:BFO_0000031 ; rdfs:label "RDF description of Neuropsychological Abnormalities Associated with Alcohol Dependence During Long-Term Rehabilitation Treatment of German Inpatients - https://fis.th-koeln.de/vivo/individual/publ_12138" , "Neuropsychological Abnormalities Associated with Alcohol Dependence During Long-Term Rehabilitation Treatment of German Inpatients" ; thkoeln:artikelnummer "1160" ; thkoeln:dokumententyp "Wissenschaftlicher Artikel" ; thkoeln:peerReviewed "true" ; thkoeln:sprache "englisch" ; thkoeln:status "validiert" ; ; ; , , ; ; "2026-04-04T08:01:17"^^xsd:dateTime ; ; ; bibo:abstract "Background: Alcohol dependence is associated with several neuropsychological abnormalities, such as increased impulsivity or attentional bias towards drug-related stimuli. However, it is debated whether these abnormalities are on the decline after long-term abstinence from alcohol. Inpatient rehabilitation treatment enables the longitudinal investigation of such variables during a long, largely secured, period of abstinence. Methods: This study involved alcohol-dependent patients consecutively admitted for a duration of 14–26 weeks to an inpatient rehabilitation treatment center located in a hospital specializing in substance use disorders. Craving and impulsivity were assessed with the means of two questionnaires (e.g., OCDS-G and BIS-11); conversely, attentional bias and problems with inhibition were measured with the help of two computer-based experiments (e.g., dot–probe task and stop–signal–reaction task). Investigations were conducted at entry, after 6 weeks, and during the last two weeks of the inpatient treatment. Results: A total of 130 patients with alcohol dependence (mean age 43.3 years; 78.5% male) completed the first, N = 102 the second, and N = 83 the final assessment. Over the whole period of inpatient treatment, there was a significant decrease in patients’ scores for both craving (t(83) = 7.8, p < 0.001) and impulsivity (t(82) = −3.75, p < 0.001, t(82) = 4.4, p < 0.001). However, there were no significant changes regarding attentional bias (t(82) = 0.16, p = 0.494) and inhibitory control (t(76) = 0.04, p = 0.482) scores. Conclusions: Neuropsychological abnormalities associated with alcohol dependence might persist even after a long abstinence period. The decrease in both craving and impulsivity levels may be explained by the protected, alcohol-free, hospital environment; however, patients’ risk of post-discharge relapse may remain high, as the basic neurobiological mechanisms of alcohol dependence may persist for long periods, and possibly for more than 3–6 months." ; bibo:doi "10.3390/brainsci14111160" ; bibo:issue "11" ; bibo:volume "14" ; vitro:mostSpecificType thkoeln:Journalartikel ; vivo:dateTimeValue ; vivo:freetextKeyword "Rehabilitation Treatment" , "Longitudinal Design" , "Stop–Signal–Reaction-Task" , "Attentional Bias" , "Impulsivity" , "Alcohol Use Disorder" , "Craving" ; vivo:hasPublicationVenue ; vivo:relatedBy , , , , . a owl:NamedIndividual , , owl:Thing ; rdfs:label "Text"@de-DE , "Text"@en-US . bibo:Document a owl:Class ; rdfs:label "Dokument"@de-DE , "Document"@en-US , "Document"@en . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . owl:Thing a owl:Class . thkoeln:Journalartikel a owl:Class ; rdfs:label "Journal Article"@en-US , "Journalartikel"@de-DE . obo:IAO_0000030 a owl:Class ; rdfs:label "Entität für Informationsinhalt"@de-DE , "Information Content Entity"@en-US , "Information Content Entity"@en . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . a thkoeln:Zitat , owl:Thing . a thkoeln:Zitat , owl:Thing . thkoeln:Publikation a owl:Class ; rdfs:label "Publikationen"@de-DE , "Publications"@en-US . a obo:BFO_0000001 , obo:BFO_0000020 , vivo:Authorship , vivo:Relationship , obo:BFO_0000002 , owl:Thing ; vivo:relates . a obo:BFO_0000003 , obo:BFO_0000008 , obo:BFO_0000001 , vivo:DateTimeValue , obo:BFO_0000148 , owl:Thing . obo:BFO_0000031 a owl:Class ; rdfs:label "Bedingter Kontinuant"@de-DE , "Generically Dependent Continuant"@en-US , "Generically Dependent Continuant"@en .